Title |
Distribution of pfmdr1 polymorphisms in Plasmodium falciparum isolated from Southern Thailand
|
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Published in |
Malaria Journal, March 2014
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DOI | 10.1186/1475-2875-13-117 |
Pubmed ID | |
Authors |
Mathirut Mungthin, Somchai Intanakom, Nantana Suwandittakul, Preeyaporn Suida, Sakultip Amsakul, Naruemon Sitthichot, Suwich Thammapalo, Saovanee Leelayoova |
Abstract |
Drug resistance in Plasmodium falciparum is a major problem in malaria control especially along the Thai-Myanmar and Thai-Cambodia borders. To date, a few molecular markers have been identified for anti-malarial resistance in P. falciparum, including the P. falciparum chloroquine resistance transporter (pfcrt) and the P. falciparum multidrug resistance 1 (pfmdr1). However no information is available regarding the distribution pattern of these gene polymorphisms in the parasites from the Thai-Malaysia border. This study was conducted to compare the distribution pattern of the pfcrt and pfmdr1 polymorphisms in the parasites from the lower southern provinces, Thai-Malaysia border and the upper southern provinces, Thai-Myanmar border. In addition, in vitro sensitivities of anti-malarial drugs including chloroquine, mefloquine, quinine, and artesunate were determined. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 3% |
Burkina Faso | 1 | 2% |
Senegal | 1 | 2% |
Unknown | 61 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 13 | 20% |
Researcher | 12 | 18% |
Student > Ph. D. Student | 10 | 15% |
Other | 7 | 11% |
Student > Doctoral Student | 6 | 9% |
Other | 9 | 14% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 17 | 26% |
Agricultural and Biological Sciences | 16 | 25% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Immunology and Microbiology | 2 | 3% |
Other | 9 | 14% |
Unknown | 11 | 17% |