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Serum-free microcarrier based production of replication deficient Influenza vaccine candidate virus lacking NS1 using Vero cells

Overview of attention for article published in BMC Biotechnology, August 2011
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Title
Serum-free microcarrier based production of replication deficient Influenza vaccine candidate virus lacking NS1 using Vero cells
Published in
BMC Biotechnology, August 2011
DOI 10.1186/1472-6750-11-81
Pubmed ID
Authors

Allen Chen, Swan Li Poh, Christian Dietzsch, Elisabeth Roethl, Mylene L Yan, Say Kong Ng

Abstract

Influenza virus is a major health concern that has huge impacts on the human society, and vaccination remains as one of the most effective ways to mitigate this disease. Comparing the two types of commercially available Influenza vaccine, the live attenuated virus vaccine is more cross-reactive and easier to administer than the traditional inactivated vaccines. One promising live attenuated Influenza vaccine that has completed Phase I clinical trial is deltaFLU, a deletion mutant lacking the viral Nonstructural Protein 1 (NS1) gene. As a consequence of this gene deletion, this mutant virus can only propagate effectively in cells with a deficient interferon-mediated antiviral response. To demonstrate the manufacturability of this vaccine candidate, a batch bioreactor production process using adherent Vero cells on microcarriers in commercially available animal-component free, serum-free media is described.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 1%
Unknown 70 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 31%
Student > Master 10 14%
Student > Ph. D. Student 9 13%
Student > Bachelor 8 11%
Student > Doctoral Student 5 7%
Other 4 6%
Unknown 13 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 24%
Engineering 9 13%
Biochemistry, Genetics and Molecular Biology 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Medicine and Dentistry 5 7%
Other 13 18%
Unknown 16 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2023.
All research outputs
#19,078,769
of 24,294,767 outputs
Outputs from BMC Biotechnology
#756
of 957 outputs
Outputs of similar age
#101,505
of 123,929 outputs
Outputs of similar age from BMC Biotechnology
#13
of 15 outputs
Altmetric has tracked 24,294,767 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 957 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 123,929 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.