Title |
The involvement of the vasa vasorum in the development of vasculitis in animal model of Kawasaki disease
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Published in |
Pediatric Rheumatology, March 2014
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DOI | 10.1186/1546-0096-12-12 |
Pubmed ID | |
Authors |
Akiko Hamaoka-Okamoto, Chinatsu Suzuki, Tomoyo Yahata, Kazuyuki Ikeda, Noriko Nagi-Miura, Naohito Ohno, Yoshinori Arai, Hideo Tanaka, Tetsuro Takamatsu, Kenji Hamaoka |
Abstract |
Kawasaki Disease (KD) involves a diffuse and systemic vasculitis of unknown etiology that mainly affects infants and children. Although a considerable number of analyses of the clinical, histopathological and molecular biological details underlying the mechanism responsible for the development of coronary arterial lesions, it is still poorly understood.The purpose of this study was to analyze the state of angiogenesis, vasculogenesis and the distribution of blood vessels using an animal model of KD like vasculitis. We investigated the involvement of the vasa vasorum from the adventitia in the vascular involvement and the development of the disease state by performing sequential histopathology, scanning electron microscopy (SEM) and micro computed tomography (CT) studies using a murine model of vasculitis induced by the Candida albicans water-soluble fraction (CAWS). |
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