Title |
Classifying short genomic fragments from novel lineages using composition and homology
|
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Published in |
BMC Bioinformatics, August 2011
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DOI | 10.1186/1471-2105-12-328 |
Pubmed ID | |
Authors |
Donovan H Parks, Norman J MacDonald, Robert G Beiko |
Abstract |
The assignment of taxonomic attributions to DNA fragments recovered directly from the environment is a vital step in metagenomic data analysis. Assignments can be made using rank-specific classifiers, which assign reads to taxonomic labels from a predetermined level such as named species or strain, or rank-flexible classifiers, which choose an appropriate taxonomic rank for each sequence in a data set. The choice of rank typically depends on the optimal model for a given sequence and on the breadth of taxonomic groups seen in a set of close-to-optimal models. Homology-based (e.g., LCA) and composition-based (e.g., PhyloPythia, TACOA) rank-flexible classifiers have been proposed, but there is at present no hybrid approach that utilizes both homology and composition. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 33% |
Mexico | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 11 | 8% |
Canada | 4 | 3% |
Spain | 3 | 2% |
Netherlands | 2 | 1% |
United Kingdom | 2 | 1% |
Denmark | 2 | 1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
Argentina | 1 | <1% |
Other | 6 | 4% |
Unknown | 105 | 76% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 46 | 33% |
Student > Ph. D. Student | 39 | 28% |
Professor > Associate Professor | 11 | 8% |
Student > Master | 10 | 7% |
Professor | 9 | 7% |
Other | 18 | 13% |
Unknown | 5 | 4% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 83 | 60% |
Biochemistry, Genetics and Molecular Biology | 15 | 11% |
Computer Science | 15 | 11% |
Medicine and Dentistry | 4 | 3% |
Immunology and Microbiology | 3 | 2% |
Other | 12 | 9% |
Unknown | 6 | 4% |