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Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control study

Overview of attention for article published in Genes and Environment, July 2017
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Title
Further evidence for the association of CYP2D6*4 gene polymorphism with Parkinson’s disease: a case control study
Published in
Genes and Environment, July 2017
DOI 10.1186/s41021-017-0078-8
Pubmed ID
Authors

Anwarullah, Muhammad Aslam, Mazhar Badshah, Rashda Abbasi, Aneesa Sultan, Kafaitullah Khan, Nafees Ahmad, Jakob von Engelhardt

Abstract

Genetic and environmental risk factors play an important role for the susceptibility to sporadic Parkinson's disease (PD). It was hypothesized that a splice variant of the CYP2D6 gene (CYP2D6*4 allele) is associated with PD because it alters the ability to metabolize toxins and in particular neurotoxins. CYP2D6 codes for the drug metabolizing enzyme debrisoquine 4-hydroxylase. The CYP2D6*4 variant results in an undetectable enzyme activity and consequently in a reduction in metabolism of some toxins. Some of agricultural chemicals have neurotoxic potential and CYP2D6 is involved in their detoxification. Thus, we conducted a case control study to investigate the association of the CYP2D6*4 with PD in a Pakistani subpopulation that is known to be exposed to high levels of some agricultural pesticides, insecticides and herbicides. We found a significantly higher allele and genotype frequency of the CYP2D6*4 variant in 174 sporadic PD patients when compared to 200 controls. In addition, there was a trend to an earlier age of PD onset and a tremor dominant phenotype in CYP2D6*4 variant carriers. Our data provide further evidence that a poor metabolizer status may increase the risk to develop PD especially in populations that are exposed to environmental toxins.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 29%
Researcher 5 13%
Other 3 8%
Student > Doctoral Student 3 8%
Student > Master 3 8%
Other 7 18%
Unknown 6 16%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Biochemistry, Genetics and Molecular Biology 8 21%
Agricultural and Biological Sciences 4 11%
Neuroscience 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 5 13%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2017.
All research outputs
#9,213,777
of 11,511,689 outputs
Outputs from Genes and Environment
#36
of 57 outputs
Outputs of similar age
#192,372
of 262,616 outputs
Outputs of similar age from Genes and Environment
#3
of 3 outputs
Altmetric has tracked 11,511,689 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 57 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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