Title |
Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
|
---|---|
Published in |
BMC Bioinformatics, April 2010
|
DOI | 10.1186/1471-2105-11-165 |
Pubmed ID | |
Authors |
Robert C McLeay, Timothy L Bailey |
Abstract |
A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine which DNA-binding transcription factors control the transcription of a set of genes by detecting enrichment of known binding motifs in the genes' regulatory regions. Typically, the biologist specifies a set of genes believed to be co-regulated and a library of known DNA-binding models for transcription factors, and MEA determines which (if any) of the factors may be direct regulators of the genes. Since the number of factors with known DNA-binding models is rapidly increasing as a result of high-throughput technologies, MEA is becoming increasingly useful. In this paper, we explore ways to make MEA applicable in more settings, and evaluate the efficacy of a number of MEA approaches. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 1% |
Germany | 4 | <1% |
France | 2 | <1% |
United Kingdom | 2 | <1% |
Sweden | 1 | <1% |
Japan | 1 | <1% |
Mexico | 1 | <1% |
Unknown | 459 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 131 | 28% |
Researcher | 95 | 20% |
Student > Bachelor | 43 | 9% |
Student > Master | 42 | 9% |
Student > Doctoral Student | 29 | 6% |
Other | 57 | 12% |
Unknown | 78 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 166 | 35% |
Biochemistry, Genetics and Molecular Biology | 150 | 32% |
Computer Science | 19 | 4% |
Medicine and Dentistry | 12 | 3% |
Engineering | 10 | 2% |
Other | 32 | 7% |
Unknown | 86 | 18% |