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Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data

Overview of attention for article published in BMC Bioinformatics, April 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page
q&a
1 Q&A thread

Citations

dimensions_citation
572 Dimensions

Readers on

mendeley
475 Mendeley
citeulike
8 CiteULike
connotea
2 Connotea
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Title
Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
Published in
BMC Bioinformatics, April 2010
DOI 10.1186/1471-2105-11-165
Pubmed ID
Authors

Robert C McLeay, Timothy L Bailey

Abstract

A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine which DNA-binding transcription factors control the transcription of a set of genes by detecting enrichment of known binding motifs in the genes' regulatory regions. Typically, the biologist specifies a set of genes believed to be co-regulated and a library of known DNA-binding models for transcription factors, and MEA determines which (if any) of the factors may be direct regulators of the genes. Since the number of factors with known DNA-binding models is rapidly increasing as a result of high-throughput technologies, MEA is becoming increasingly useful. In this paper, we explore ways to make MEA applicable in more settings, and evaluate the efficacy of a number of MEA approaches.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 475 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 1%
Germany 4 <1%
France 2 <1%
United Kingdom 2 <1%
Sweden 1 <1%
Japan 1 <1%
Mexico 1 <1%
Unknown 459 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 131 28%
Researcher 95 20%
Student > Bachelor 43 9%
Student > Master 42 9%
Student > Doctoral Student 29 6%
Other 57 12%
Unknown 78 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 166 35%
Biochemistry, Genetics and Molecular Biology 150 32%
Computer Science 19 4%
Medicine and Dentistry 12 3%
Engineering 10 2%
Other 32 7%
Unknown 86 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2020.
All research outputs
#3,598,731
of 22,649,029 outputs
Outputs from BMC Bioinformatics
#1,333
of 7,234 outputs
Outputs of similar age
#15,682
of 95,421 outputs
Outputs of similar age from BMC Bioinformatics
#13
of 65 outputs
Altmetric has tracked 22,649,029 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,234 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,421 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.