Title |
mtDNA haplogroup and single nucleotide polymorphisms structure human microbiome communities
|
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Published in |
BMC Genomics, April 2014
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DOI | 10.1186/1471-2164-15-257 |
Pubmed ID | |
Authors |
Jun Ma, Cristian Coarfa, Xiang Qin, Penelope E Bonnen, Aleksandar Milosavljevic, James Versalovic, Kjersti Aagaard |
Abstract |
Although our microbial community and genomes (the human microbiome) outnumber our genome by several orders of magnitude, to what extent the human host genetic complement informs the microbiota composition is not clear. The Human Microbiome Project (HMP) Consortium established a unique population-scale framework with which to characterize the relationship of microbial community structure with their human hosts. A wide variety of taxa and metabolic pathways have been shown to be differentially distributed by virtue of race/ethnicity in the HMP. Given that mtDNA haplogroups are the maternally derived ancestral genomic markers and mitochondria's role as the generator for cellular ATP, characterizing the relationship between human mtDNA genomic variants and microbiome profiles becomes of potential marked biologic and clinical interest. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Sri Lanka | 1 | 33% |
France | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 4 | 2% |
United Kingdom | 1 | <1% |
Denmark | 1 | <1% |
Germany | 1 | <1% |
Unknown | 170 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 23% |
Researcher | 26 | 15% |
Student > Master | 20 | 11% |
Student > Bachelor | 17 | 10% |
Student > Doctoral Student | 10 | 6% |
Other | 28 | 16% |
Unknown | 35 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 57 | 32% |
Biochemistry, Genetics and Molecular Biology | 25 | 14% |
Medicine and Dentistry | 19 | 11% |
Immunology and Microbiology | 11 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 16 | 9% |
Unknown | 45 | 25% |