Title |
Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice
|
---|---|
Published in |
Cancer & Metabolism, March 2014
|
DOI | 10.1186/2049-3002-2-6 |
Pubmed ID | |
Authors |
Kristyn A Liu, Laura M Lashinger, Audrey J Rasmussen, Stephen D Hursting |
Abstract |
The risk of pancreatic cancer, the 4th deadliest cancer for both men and women in the United States, is increased by obesity. Calorie restriction (CR) is a well-known dietary regimen that prevents or reverses obesity and suppresses tumorigenesis in a variety of animal models, at least in part via inhibition of mammalian target of rapamycin (mTOR) signaling. Branched-chain amino acids (BCAA), especially leucine, activate mTOR and enhance growth and proliferation of myocytes and epithelial cells, which is why leucine is a popular supplement among athletes. Leucine is also increasingly being used as a treatment for pancreatic cancer cachexia, but the effects of leucine supplementation on pancreatic tumor growth have not been elucidated. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Norway | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 79 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 22% |
Researcher | 11 | 14% |
Student > Master | 10 | 13% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 5 | 6% |
Other | 12 | 15% |
Unknown | 17 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 23% |
Agricultural and Biological Sciences | 13 | 16% |
Medicine and Dentistry | 12 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Nursing and Health Professions | 4 | 5% |
Other | 6 | 8% |
Unknown | 20 | 25% |