Title |
T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?
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Published in |
Arthritis Research & Therapy, March 2014
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DOI | 10.1186/ar4499 |
Pubmed ID | |
Authors |
Zana Brkic, Odilia BJ Corneth, Cornelia G van Helden-Meeuwsen, Radboud JEM Dolhain, Naomi I Maria, Sandra MJ Paulissen, Nadine Davelaar, Jan Piet van Hamburg, Paul L van Daele, Virgil A Dalm, P Martin van Hagen, Johanna MW Hazes, Marjan A Versnel, Erik Lubberts |
Abstract |
A hallmark of systemic autoimmune diseases like systemic lupus erythematosus (SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN type I signature. Recently, T helper 17 subset (Th17 cells), which produces IL-17A, IL-17F, IL-21 and IL-22, has been implicated in SLE. As CCR6 enriches for Th17 cells, we used this approach to investigate whether CCR6+ memory T helper cells producing IL-17A, IL-17F, IL-21 and/or IL-22 are increased in SLE patients and whether this increase is related to the presence of IFN type I signature. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Spain | 1 | 2% |
United States | 1 | 2% |
Netherlands | 1 | 2% |
Unknown | 37 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 22% |
Researcher | 6 | 15% |
Student > Master | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 4 | 10% |
Other | 8 | 20% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 39% |
Agricultural and Biological Sciences | 8 | 20% |
Immunology and Microbiology | 6 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Psychology | 2 | 5% |
Other | 0 | 0% |
Unknown | 5 | 12% |