Title |
Hyperammonemia due to urea cycle disorders: a potentially fatal condition in the intensive care setting
|
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Published in |
Journal of Intensive Care, March 2014
|
DOI | 10.1186/2052-0492-2-22 |
Pubmed ID | |
Authors |
MarcelCerqueira Cesar Machado, Fabiano Pinheiro da Silva |
Abstract |
Disorders of the urea cycle are secondary to a defect in the system that converts ammonia into urea, resulting in accumulation of ammonia and other products. This results in encephalopathy, coma, and death if not recognized and treated rapidly. Late-onset urea cycle disorders may be precipitated by acute disease and can be difficult to recognize because patients are already ill. Diagnosis of urea cycle disorders is based on clinical suspicion and determination of blood ammonia in suspected patients with neurological symptoms in the intensive care setting. Treatment is based on the removal of ammonia by dialysis or hemofiltration, reduction of the catabolic state, abolishment of nitrogen administration, and use of pharmacological nitrogen scavenging agents. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 14% |
United States | 2 | 14% |
Mexico | 1 | 7% |
Ecuador | 1 | 7% |
Spain | 1 | 7% |
Unknown | 7 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 79% |
Practitioners (doctors, other healthcare professionals) | 2 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 2% |
Unknown | 62 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 14% |
Student > Bachelor | 9 | 14% |
Other | 8 | 13% |
Researcher | 5 | 8% |
Student > Master | 4 | 6% |
Other | 8 | 13% |
Unknown | 20 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 30% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Chemistry | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 4 | 6% |
Unknown | 23 | 37% |