Title |
Green tea: a new option for the prevention or control of osteoarthritis
|
---|---|
Published in |
Arthritis Research & Therapy, August 2011
|
DOI | 10.1186/ar3428 |
Pubmed ID | |
Authors |
Santosh K Katiyar, Chander Raman |
Abstract |
IL-1β is a major cytokine driving the inflammatory processes leading to the pathophysiology of osteoarthritis and other inflammatory diseases. Blockade of IL-1β activity using substances such as the naturally occurring IL-1 receptor antagonist or anti-IL-1β monoclonal antibody are currently being used or tested as therapy. However, such treatments are ineffective in osteoarthritis. In a recent study, epigallocatechin-3-gallate, a green tea polyphenol, was found to be effective in reducing IL-1β-induced inflammatory cytokines, TNFα, IL-6, granulocyte-macrophage colony-stimulating factor and several chemokines from human chondrocytes. The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1β activity by increasing effectiveness and/or reducing dosage. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
Portugal | 1 | 2% |
Unknown | 45 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 21% |
Researcher | 5 | 11% |
Student > Ph. D. Student | 5 | 11% |
Professor > Associate Professor | 4 | 9% |
Student > Master | 4 | 9% |
Other | 6 | 13% |
Unknown | 13 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 21% |
Nursing and Health Professions | 6 | 13% |
Agricultural and Biological Sciences | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 5 | 11% |
Unknown | 16 | 34% |