Title |
Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells
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Published in |
BMC Cancer, December 2013
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DOI | 10.1186/1471-2407-13-574 |
Pubmed ID | |
Authors |
Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, Martin Jung, Johannes Linxweiler, Frank Langer, Hans-Joachim Schäfers, Adolfo Cavalié, Richard Zimmermann, Markus Greiner |
Abstract |
Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca²⁺. SEC62 silencing leads to elevated cytosolic Ca²⁺ and increased ER Ca²⁺ leakage after thapsigargin treatment. Sec62 protein levels are significantly increased in different tumors, including prostate, lung and thyroid cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 19% |
Student > Ph. D. Student | 9 | 19% |
Student > Bachelor | 7 | 15% |
Student > Master | 6 | 13% |
Other | 5 | 10% |
Other | 6 | 13% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 25% |
Biochemistry, Genetics and Molecular Biology | 10 | 21% |
Medicine and Dentistry | 8 | 17% |
Engineering | 2 | 4% |
Environmental Science | 1 | 2% |
Other | 4 | 8% |
Unknown | 11 | 23% |