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Challenges in machine perfusion preservation for liver grafts from donation after circulatory death

Overview of attention for article published in Transplantation Research, November 2013
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Title
Challenges in machine perfusion preservation for liver grafts from donation after circulatory death
Published in
Transplantation Research, November 2013
DOI 10.1186/2047-1440-2-19
Pubmed ID
Authors

Naoto Matsuno, Eiji Kobayashi

Abstract

Donation after circulatory death (DCD) is a promising solution to the critical shortage of donor graft tissue. Maintaining organ viability after donation until transplantation is essential for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in clinical practice. However, ischemic damage present in DCD grafts jeopardizes organ viability during cold storage, and whether static cold storage is the most effective method to prevent deterioration of organ quality in the increasing numbers of organs from DCD is unknown. Here we describe the historical background of DCD liver grafts and a new preservation method for experimental and clinical transplantation. To prevent ischemia-reperfusion injury in DCD liver grafts, a hypothermic machine perfusion (HMP) technique has recently been developed and may be superior to static cold preservation. We present evidence supporting the need for improving liver perfusion performance and discuss how doing so will benefit liver transplantation recipients.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Arab Emirates 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 26%
Student > Ph. D. Student 6 14%
Student > Bachelor 6 14%
Student > Master 4 10%
Student > Doctoral Student 3 7%
Other 6 14%
Unknown 6 14%
Readers by discipline Count As %
Medicine and Dentistry 18 43%
Engineering 4 10%
Agricultural and Biological Sciences 4 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Other 1 2%
Unknown 10 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2014.
All research outputs
#20,041,143
of 24,631,014 outputs
Outputs from Transplantation Research
#30
of 38 outputs
Outputs of similar age
#243,546
of 318,025 outputs
Outputs of similar age from Transplantation Research
#7
of 7 outputs
Altmetric has tracked 24,631,014 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 38 research outputs from this source. They receive a mean Attention Score of 3.7. This one scored the same or higher as 8 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,025 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.