↓ Skip to main content

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

Overview of attention for article published in Molecular Cancer, March 2014
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
138 Dimensions

Readers on

mendeley
56 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
Published in
Molecular Cancer, March 2014
DOI 10.1186/1476-4598-13-66
Pubmed ID
Authors

Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M Luk, Tapas K Kundu

Abstract

Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for both prevention and treatment of HCC. Here we report, garcinol, a polyisoprenylated benzophenone, could suppress STAT3 activation in HCC cell lines and in xenografted tumor of HCC in nude mice model.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 21%
Researcher 8 14%
Student > Bachelor 6 11%
Student > Master 6 11%
Student > Doctoral Student 4 7%
Other 9 16%
Unknown 11 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 23%
Agricultural and Biological Sciences 10 18%
Medicine and Dentistry 6 11%
Chemistry 5 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 6 11%
Unknown 12 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2014.
All research outputs
#16,528,366
of 20,553,550 outputs
Outputs from Molecular Cancer
#1,153
of 1,560 outputs
Outputs of similar age
#146,931
of 205,431 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 20,553,550 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,560 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,431 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them