Title |
Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo
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Published in |
Molecular Cancer, March 2014
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DOI | 10.1186/1476-4598-13-66 |
Pubmed ID | |
Authors |
Gautam Sethi, Snehajyoti Chatterjee, Peramaiyan Rajendran, Feng Li, Muthu K Shanmugam, Kwong Fai Wong, Alan Prem Kumar, Parijat Senapati, Amit K Behera, Kam Man Hui, Jeelan Basha, Nagashayana Natesh, John M Luk, Tapas K Kundu |
Abstract |
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for both prevention and treatment of HCC. Here we report, garcinol, a polyisoprenylated benzophenone, could suppress STAT3 activation in HCC cell lines and in xenografted tumor of HCC in nude mice model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Hungary | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 21% |
Researcher | 10 | 15% |
Student > Master | 6 | 9% |
Student > Bachelor | 6 | 9% |
Student > Doctoral Student | 4 | 6% |
Other | 12 | 18% |
Unknown | 16 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 25% |
Agricultural and Biological Sciences | 11 | 16% |
Medicine and Dentistry | 6 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
Chemistry | 5 | 7% |
Other | 9 | 13% |
Unknown | 15 | 22% |