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CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls

Overview of attention for article published in BMC Pediatrics, March 2014
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Title
CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls
Published in
BMC Pediatrics, March 2014
DOI 10.1186/1471-2431-14-78
Pubmed ID
Authors

Theresa Ryan Stueve, Mary S Wolff, Ashley Pajak, Susan L Teitelbaum, Jia Chen

Abstract

Childhood obesity and early puberty are intermediate risk factors for later metabolic and reproductive disorders including diabetes, polycystic ovarian syndrome (PCOS), and breast cancer. Atypical methylation patterns in genes related to hormone and adipose metabolism, such as CYP19A1 (aromatase) and PPARG (peroxisome proliferator-activated receptor gamma), are associated with alterations in gene expression which may contribute to pathogenesis of these diseases. If present in early life, it is conceivable similar methylation aberrations may result in hormone perturbations that alter pubertal timing.

X Demographics

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 21%
Researcher 9 14%
Student > Bachelor 8 13%
Student > Master 6 10%
Student > Doctoral Student 4 6%
Other 11 17%
Unknown 12 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 17%
Biochemistry, Genetics and Molecular Biology 9 14%
Medicine and Dentistry 9 14%
Nursing and Health Professions 5 8%
Psychology 3 5%
Other 9 14%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2014.
All research outputs
#15,298,293
of 22,751,628 outputs
Outputs from BMC Pediatrics
#2,025
of 2,990 outputs
Outputs of similar age
#131,749
of 223,366 outputs
Outputs of similar age from BMC Pediatrics
#39
of 60 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,990 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,366 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.