Title |
Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7
|
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Published in |
BMC Neuroscience, March 2014
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DOI | 10.1186/1471-2202-15-38 |
Pubmed ID | |
Authors |
Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel, Markus Schwaninger |
Abstract |
Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the 'ribosomal skip' promoting 2A peptide-bridge. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 6% |
Unknown | 34 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 17% |
Student > Ph. D. Student | 6 | 17% |
Researcher | 5 | 14% |
Student > Bachelor | 4 | 11% |
Professor > Associate Professor | 3 | 8% |
Other | 5 | 14% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 12 | 33% |
Medicine and Dentistry | 5 | 14% |
Neuroscience | 5 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Psychology | 1 | 3% |
Other | 3 | 8% |
Unknown | 8 | 22% |