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Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

Overview of attention for article published in BMC Neuroscience, March 2014
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Title
Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7
Published in
BMC Neuroscience, March 2014
DOI 10.1186/1471-2202-15-38
Pubmed ID
Authors

Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel, Markus Schwaninger

Abstract

Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the 'ribosomal skip' promoting 2A peptide-bridge.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 6%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Student > Ph. D. Student 6 17%
Researcher 5 14%
Student > Bachelor 4 11%
Professor > Associate Professor 3 8%
Other 5 14%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 33%
Medicine and Dentistry 5 14%
Neuroscience 5 14%
Biochemistry, Genetics and Molecular Biology 2 6%
Psychology 1 3%
Other 3 8%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2014.
All research outputs
#20,226,756
of 22,751,628 outputs
Outputs from BMC Neuroscience
#1,052
of 1,242 outputs
Outputs of similar age
#189,339
of 220,823 outputs
Outputs of similar age from BMC Neuroscience
#24
of 26 outputs
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So far Altmetric has tracked 1,242 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.