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Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7

Overview of attention for article published in BMC Neuroscience, March 2014
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Title
Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7
Published in
BMC Neuroscience, March 2014
DOI 10.1186/1471-2202-15-38
Pubmed ID
Authors

Ann-Marie Heinonen, Mahbubur Rahman, Godwin Dogbevia, Hannah Jakobi, Stefan Wölfl, Rolf Sprengel, Markus Schwaninger

Abstract

Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functionally active BMPs, we expressed BMP7, BMP2 and the BMP inhibitor Noggin under the control of rAAV vectors in vivo. For visual control of rAAV-mediated BMP (v-BMP) expression we fused the secreted morphogenic polypeptides and the fluorescent reporter protein Venus via the 'ribosomal skip' promoting 2A peptide-bridge.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 6%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 17%
Student > Master 6 17%
Researcher 5 14%
Student > Bachelor 4 11%
Professor > Associate Professor 3 8%
Other 5 14%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 36%
Medicine and Dentistry 5 14%
Neuroscience 5 14%
Psychology 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 6%
Unknown 9 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2014.
All research outputs
#10,994,835
of 12,372,276 outputs
Outputs from BMC Neuroscience
#821
of 993 outputs
Outputs of similar age
#162,417
of 194,089 outputs
Outputs of similar age from BMC Neuroscience
#3
of 3 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 993 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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