Title |
Effectiveness of lithium in subjects with treatment-resistant depression and suicide risk: a protocol for a randomised, independent, pragmatic, multicentre, parallel-group, superiority clinical trial
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Published in |
BMC Psychiatry, August 2013
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DOI | 10.1186/1471-244x-13-212 |
Pubmed ID | |
Authors |
Andrea Cipriani, Francesca Girlanda, Emilia Agrimi, Andrea Barichello, Rossella Beneduce, Irene Bighelli, Giulia Bisoffi, Alfredo Bisogno, Paola Bortolaso, Marianna Boso, Carmela Calandra, Liliana Cascone, Caterina Corbascio, Vincenzo Fricchione Parise, Francesco Gardellin, Daniele Gennaro, Batul Hanife, Camilla Lintas, Marina Lorusso, Chiara Luchetta, Claudio Lucii, Francesco Cernuto, Fiorella Tozzi, Alessandra Marsilio, Francesca Maio, Chiara Mattei, Daniele Moretti, Maria Grazia Appino, Michela Nosè, Guglielmo Occhionero, Duccio Papanti, Damiano Pecile, Marianna Purgato, Davide Prestia, Francesco Restaino, Tiziana Sciarma, Alessandra Ruberto, Stefania Strizzolo, Stefania Tamborini, Orlando Todarello, Simona Ziero, Spyridon Zotos, Corrado Barbui |
Abstract |
Data on therapeutic interventions following deliberate self harm (DSH) in patients with treatment-resistant depression (TRD) are very scant and there is no unanimous consensus on the best pharmacological option for these patients. There is some evidence that lithium treatment might be effective in reducing the risk of completed suicide in adult patients with unipolar affective disorders, however no clear cut results have been found so far. The primary aim of the present study is to assess whether adding lithium to standard therapy is an effective treatment strategy to reduce the risk of suicidal behaviour in long term treatment of people with TRD and previous history of DSH. |
X Demographics
Geographical breakdown
Country | Count | As % |
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India | 1 | 33% |
Brazil | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 1% |
Australia | 1 | 1% |
Unknown | 95 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 15% |
Student > Bachelor | 14 | 14% |
Student > Master | 10 | 10% |
Student > Ph. D. Student | 9 | 9% |
Student > Postgraduate | 7 | 7% |
Other | 14 | 14% |
Unknown | 28 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 28% |
Psychology | 20 | 21% |
Agricultural and Biological Sciences | 6 | 6% |
Social Sciences | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 6 | 6% |
Unknown | 31 | 32% |