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Nerve growth factor: from the early discoveries to the potential clinical use

Overview of attention for article published in Journal of Translational Medicine, November 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#47 of 4,538)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
24 news outlets
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2 X users
patent
4 patents
wikipedia
1 Wikipedia page
reddit
1 Redditor

Citations

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353 Dimensions

Readers on

mendeley
419 Mendeley
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Title
Nerve growth factor: from the early discoveries to the potential clinical use
Published in
Journal of Translational Medicine, November 2012
DOI 10.1186/1479-5876-10-239
Pubmed ID
Authors

Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi, Luigi Manni

Abstract

The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems. NGF plays its trophic role both during development and in adulthood, ensuring the maintenance of phenotypic and functional characteristic of several populations of neurons as well as immune cells. From a translational standpoint, the action of NGF on cholinergic neurons of the basal forebrain and on sensory neurons in dorsal root ganglia first gained researcher's attention, in view of possible clinical use in Alzheimer's disease patients and in peripheral neuropathies respectively. The translational and clinical research on NGF have, since then, enlarged the spectrum of diseases that could benefit from NGF treatment, at the same time highlighting possible limitations in the use of the neurotrophin as a drug. In this review we give a comprehensive account for almost all of the clinical trials attempted until now by using NGF. A perspective on future development for translational research on NGF is also discussed, in view of recent proposals for innovative delivery strategies and/or for additional pathologies to be treated, such as ocular and skin diseases, gliomas, traumatic brain injuries, vascular and immune diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 419 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 <1%
France 2 <1%
Netherlands 2 <1%
China 1 <1%
Argentina 1 <1%
Unknown 409 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 66 16%
Student > Bachelor 65 16%
Student > Master 56 13%
Researcher 44 11%
Other 22 5%
Other 64 15%
Unknown 102 24%
Readers by discipline Count As %
Medicine and Dentistry 70 17%
Agricultural and Biological Sciences 67 16%
Biochemistry, Genetics and Molecular Biology 50 12%
Neuroscience 45 11%
Pharmacology, Toxicology and Pharmaceutical Science 12 3%
Other 63 15%
Unknown 112 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 204. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#187,510
of 25,013,816 outputs
Outputs from Journal of Translational Medicine
#47
of 4,538 outputs
Outputs of similar age
#1,154
of 289,432 outputs
Outputs of similar age from Journal of Translational Medicine
#2
of 93 outputs
Altmetric has tracked 25,013,816 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,538 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.