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Nerve growth factor: from the early discoveries to the potential clinical use

Overview of attention for article published in Journal of Translational Medicine, November 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)

Mentioned by

1 tweeter
1 Wikipedia page
1 Redditor

Readers on

333 Mendeley
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Nerve growth factor: from the early discoveries to the potential clinical use
Published in
Journal of Translational Medicine, November 2012
DOI 10.1186/1479-5876-10-239
Pubmed ID

Luigi Aloe, Maria Luisa Rocco, Patrizia Bianchi, Luigi Manni


The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems. NGF plays its trophic role both during development and in adulthood, ensuring the maintenance of phenotypic and functional characteristic of several populations of neurons as well as immune cells. From a translational standpoint, the action of NGF on cholinergic neurons of the basal forebrain and on sensory neurons in dorsal root ganglia first gained researcher's attention, in view of possible clinical use in Alzheimer's disease patients and in peripheral neuropathies respectively. The translational and clinical research on NGF have, since then, enlarged the spectrum of diseases that could benefit from NGF treatment, at the same time highlighting possible limitations in the use of the neurotrophin as a drug. In this review we give a comprehensive account for almost all of the clinical trials attempted until now by using NGF. A perspective on future development for translational research on NGF is also discussed, in view of recent proposals for innovative delivery strategies and/or for additional pathologies to be treated, such as ocular and skin diseases, gliomas, traumatic brain injuries, vascular and immune diseases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 333 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 1%
Netherlands 2 <1%
France 2 <1%
China 1 <1%
Argentina 1 <1%
Unknown 323 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 19%
Student > Bachelor 51 15%
Student > Master 48 14%
Researcher 41 12%
Student > Postgraduate 19 6%
Other 52 16%
Unknown 59 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 64 19%
Medicine and Dentistry 60 18%
Biochemistry, Genetics and Molecular Biology 41 12%
Neuroscience 38 11%
Pharmacology, Toxicology and Pharmaceutical Science 12 4%
Other 47 14%
Unknown 71 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 December 2020.
All research outputs
of 19,839,988 outputs
Outputs from Journal of Translational Medicine
of 3,486 outputs
Outputs of similar age
of 203,931 outputs
Outputs of similar age from Journal of Translational Medicine
of 1 outputs
Altmetric has tracked 19,839,988 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,486 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them