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Detection of a TRAF1-ALK fusion in an anaplastic large cell lymphoma patient with chemotherapy and ALK inhibitor-resistant disease

Overview of attention for article published in BMC Research Notes, July 2015
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Title
Detection of a TRAF1-ALK fusion in an anaplastic large cell lymphoma patient with chemotherapy and ALK inhibitor-resistant disease
Published in
BMC Research Notes, July 2015
DOI 10.1186/s13104-015-1277-7
Pubmed ID
Authors

Kasey Lawrence, Brian Berry, John Handshoe, David Hout, Rosetta Mazzola, Stephan W Morris, David L Saltman

Abstract

The anaplastic lymphoma kinase (ALK) gene encodes a receptor tyrosine kinase, which was first identified as the fusion partner of the nucleophosmin (NPM1) gene in the recurrent t(2;5)(p23;q35) found in a subset of anaplastic large cell lymphoma (ALCL). Several distinct, non-NPM1, ALK fusions have subsequently been described in lymphomas and other tumor types. All of these fusions result in the constitutive expression and activation of ALK and ALK signaling pathways, ultimately leading to the malignant phenotype. A non-NPM1 fusion partner of ALK was identified in a 32-year-old Caucasian male ALCL patient whose disease was refractory to standard chemotherapy and autologous stem cell transplantation, and exhibited a poor response to a first-generation ALK inhibitor. Non-allele-specific ALK RT-qPCR revealed ALK overexpression and 5' RACE PCR revealed that the patient's lymphoma expressed a TRAF1-ALK fusion. We report the case of an ALCL patient whose tumor harbored the newly recognized TRAF1-ALK fusion and describe the clinical outcome after treatment with an ALK inhibitor. The short survival of our patient may reflect a propensity toward aggressive behavior in lymphomas that express this ALK fusion.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Researcher 3 38%
Lecturer 1 13%
Other 1 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 38%
Environmental Science 1 13%
Biochemistry, Genetics and Molecular Biology 1 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 13%
Immunology and Microbiology 1 13%
Other 1 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2022.
All research outputs
#20,882,385
of 23,500,709 outputs
Outputs from BMC Research Notes
#3,606
of 4,309 outputs
Outputs of similar age
#222,283
of 265,367 outputs
Outputs of similar age from BMC Research Notes
#79
of 100 outputs
Altmetric has tracked 23,500,709 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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