Title |
Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes
|
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Published in |
BMC Neuroscience, April 2014
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DOI | 10.1186/1471-2202-15-47 |
Pubmed ID | |
Authors |
Golime RamaRao, Prachiti Afley, Jyothiranjan Acharya, Bijoy Krishna Bhattacharya |
Abstract |
Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Acute nerve agent exposure can cause rapid death or leads to multiple and long term neurological effects. The biochemical changes that occur following nerve agent exposure needs to be elucidated to understand the mechanisms behind their long term neurological effects and to design better therapeutic drugs to block their multiple neurotoxic effects. In the present study, we intend to study the efficacy of antidotes comprising of HI-6 (1-[[[4-(aminocarbonyl)-pyridinio]-methoxy]-methyl]-2-[(hydroxyimino) methyl] pyridinium dichloride), atropine and midazolam on soman induced neurodegeneration and the expression of c-Fos, Calpain, and Bax levels in discrete rat brain areas. |
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United States | 3 | 5% |
El Salvador | 1 | 2% |
Korea, Democratic People's Republic of | 1 | 2% |
Australia | 1 | 2% |
Unknown | 33 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 54 | 98% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 3% |
United States | 1 | 3% |
Unknown | 35 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 24% |
Student > Ph. D. Student | 6 | 16% |
Student > Doctoral Student | 4 | 11% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Other | 5 | 14% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 16% |
Chemistry | 6 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 4 | 11% |
Unknown | 6 | 16% |