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The R-spondin protein family

Overview of attention for article published in Genome Biology, March 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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3 X users
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9 patents

Citations

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230 Dimensions

Readers on

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325 Mendeley
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1 CiteULike
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Title
The R-spondin protein family
Published in
Genome Biology, March 2012
DOI 10.1186/gb-2012-13-3-242
Pubmed ID
Authors

Wim BM de Lau, Berend Snel, Hans C Clevers

Abstract

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin signaling pathway. These proteins are approximately 35 kDa, and are characterized by two amino-terminal furin-like repeats, which are necessary and sufficient for Wnt signal potentiation, and a thrombospondin domain situated more towards the carboxyl terminus that can bind matrix glycosaminoglycans and/or proteoglycans. Although R-spondins are unable to initiate Wnt signaling, they can potently enhance responses to low-dose Wnt proteins. In humans, rare disruptions of the gene encoding R-spondin1 cause a syndrome of XX sex reversal (phenotypic male), palmoplantar keratosis (a thickening of the palms and soles caused by excess keratin formation) and predisposition to squamous cell carcinoma of the skin. Mutations in the gene encoding R-spondin4 cause anonychia (absence or hypoplasia of nails on fingers and toes). Recently, leucine-rich repeat-containing G-protein-coupled receptor (Lgr)4, Lgr5 and Lgr6, three closely related orphans of the leucine-rich repeat family of G-protein-coupled receptors, have been identified as receptors for R-spondins. Lgr5 and Lgr6 are markers for adult stem cells. Because R-spondins are potent stimulators of adult stem cell proliferation in vivo and in vitro, these findings might guide the therapeutic use of R-spondins in regenerative medicine.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 325 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
France 2 <1%
United Kingdom 2 <1%
Netherlands 1 <1%
Portugal 1 <1%
Poland 1 <1%
Unknown 316 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 64 20%
Researcher 60 18%
Student > Master 48 15%
Student > Bachelor 37 11%
Other 15 5%
Other 48 15%
Unknown 53 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 108 33%
Biochemistry, Genetics and Molecular Biology 93 29%
Medicine and Dentistry 30 9%
Pharmacology, Toxicology and Pharmaceutical Science 7 2%
Immunology and Microbiology 7 2%
Other 19 6%
Unknown 61 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#3,274,682
of 25,374,647 outputs
Outputs from Genome Biology
#2,368
of 4,467 outputs
Outputs of similar age
#20,034
of 172,657 outputs
Outputs of similar age from Genome Biology
#21
of 41 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,657 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.