Title |
The lamin protein family
|
---|---|
Published in |
Genome Biology, May 2011
|
DOI | 10.1186/gb-2011-12-5-222 |
Pubmed ID | |
Authors |
Travis A Dittmer, Tom Misteli |
Abstract |
The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability. They have been implicated in a wide range of nuclear functions, including higher-order genome organization, chromatin regulation, transcription, DNA replication and DNA repair. The lamins are members of the intermediate filament (IF) family of proteins, which constitute a major component of the cytoskeleton. Lamins are the only nuclear IFs and are the ancestral founders of the IF protein superfamily. Lamins polymerize into fibers forming a complex protein meshwork in vivo and, like all IF proteins, have a tripartite structure with two globular head and tail domains flanking a central α-helical rod domain, which supports the formation of higher-order polymers. Mutations in lamins cause a large number of diverse human diseases, collectively known as the laminopathies, underscoring their functional importance. |
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Geographical breakdown
Country | Count | As % |
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Japan | 3 | <1% |
United Kingdom | 3 | <1% |
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Italy | 1 | <1% |
Portugal | 1 | <1% |
Russia | 1 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Other | 1 | <1% |
Unknown | 556 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 125 | 22% |
Student > Master | 85 | 15% |
Student > Bachelor | 81 | 14% |
Researcher | 74 | 13% |
Student > Doctoral Student | 31 | 5% |
Other | 63 | 11% |
Unknown | 114 | 20% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 140 | 24% |
Medicine and Dentistry | 31 | 5% |
Engineering | 19 | 3% |
Chemistry | 13 | 2% |
Other | 51 | 9% |
Unknown | 133 | 23% |