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Limited efficacy of West Nile virus vaccines in large falcons (Falco spp.)

Overview of attention for article published in Veterinary Research, April 2014
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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35 Mendeley
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Title
Limited efficacy of West Nile virus vaccines in large falcons (Falco spp.)
Published in
Veterinary Research, April 2014
DOI 10.1186/1297-9716-45-41
Pubmed ID
Authors

Joke Angenvoort, Dominik Fischer, Christine Fast, Ute Ziegler, Martin Eiden, Jorge Garcia de la Fuente, Michael Lierz, Martin H Groschup

Abstract

West Nile virus (WNV) can lead to fatal diseases in raptor species. Unfortunately, there is no vaccine which has been designed specifically for use in breeding stocks of falcons. Therefore the immunogenicity and protective capacity of two commercially available WNV vaccines, both approved for use in horses, were evaluated in large falcons. One vaccine contained adjuvanted inactivated WNV lineage 1 immunogens, while the second represented a canarypox recombinant live virus vector vaccine. The efficacy of different vaccination regimes for these two vaccines was assessed serologically and by challenging the falcons with a WNV strain of homologous lineage 1. Our studies show that the recombinant vaccine conveys a slightly better protection than the inactivated vaccine, but moderate (recombinant vaccine) or weak (inactivated vaccine) side effects were observed at the injection sites. Using the recommended 2-dose regimen, both vaccines elicited only sub-optimal antibody responses and gave only partial protection following WNV challenge. Better results were obtained for both vaccines after a third dose, i.e. alleviation of clinical signs, absence of fatalities and reduction of virus shedding and viraemia. Therefore the consequences of WNV infections in falcons can be clearly alleviated by vaccination, especially if the amended triple administration scheme is used, although side effects at the vaccination site must be accepted.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 17%
Other 5 14%
Researcher 4 11%
Student > Master 4 11%
Student > Doctoral Student 3 9%
Other 7 20%
Unknown 6 17%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 11 31%
Agricultural and Biological Sciences 6 17%
Immunology and Microbiology 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2014.
All research outputs
#7,030,338
of 25,374,917 outputs
Outputs from Veterinary Research
#320
of 1,337 outputs
Outputs of similar age
#63,292
of 241,185 outputs
Outputs of similar age from Veterinary Research
#4
of 24 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,185 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.