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Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices

Overview of attention for article published in Veterinary Research, April 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

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3 X users
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1 patent

Citations

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39 Dimensions

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71 Mendeley
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Title
Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices
Published in
Veterinary Research, April 2014
DOI 10.1186/1297-9716-45-42
Pubmed ID
Authors

Mario Delgado-Ortega, Sandrine Melo, Darsaniya Punyadarsaniya, Christelle Ramé, Michel Olivier, Denis Soubieux, Daniel Marc, Gaëlle Simon, Georg Herrler, Mustapha Berri, Joëlle Dupont, François Meurens

Abstract

Viral respiratory diseases remain of major importance in swine breeding units. Swine influenza virus (SIV) is one of the main known contributors to infectious respiratory diseases. The innate immune response to swine influenza viruses has been assessed in many previous studies. However most of these studies were carried out in a single-cell population or directly in the live animal, in all its complexity. In the current study we report the use of a trachea epithelial cell line (newborn pig trachea cells - NPTr) in comparison with alveolar macrophages and lung slices for the characterization of innate immune response to an infection by a European SIV of the H3N2 subtype. The expression pattern of transcripts involved in the recognition of the virus, interferon type I and III responses, and the host-response regulation were assessed by quantitative PCR in response to infection. Some significant differences were observed between the three systems, notably in the expression of type III interferon mRNA. Then, results show a clear induction of JAK/STAT and MAPK signaling pathways in infected NPTr cells. Conversely, PI3K/Akt signaling pathways was not activated. The inhibition of the JAK/STAT pathway clearly reduced interferon type I and III responses and the induction of SOCS1 at the transcript level in infected NPTr cells. Similarly, the inhibition of MAPK pathway reduced viral replication and interferon response. All together, these results contribute to an increased understanding of the innate immune response to H3N2 SIV and may help identify strategies to effectively control SIV infection.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 1%
Canada 1 1%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 23%
Student > Ph. D. Student 16 23%
Researcher 13 18%
Student > Bachelor 5 7%
Student > Doctoral Student 4 6%
Other 8 11%
Unknown 9 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 27%
Immunology and Microbiology 12 17%
Veterinary Science and Veterinary Medicine 10 14%
Biochemistry, Genetics and Molecular Biology 5 7%
Medicine and Dentistry 5 7%
Other 9 13%
Unknown 11 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2021.
All research outputs
#7,204,326
of 25,371,288 outputs
Outputs from Veterinary Research
#330
of 1,337 outputs
Outputs of similar age
#65,259
of 241,343 outputs
Outputs of similar age from Veterinary Research
#6
of 23 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,343 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.