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Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis

Overview of attention for article published in BMC Musculoskeletal Disorders, April 2014
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Title
Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis
Published in
BMC Musculoskeletal Disorders, April 2014
DOI 10.1186/1471-2474-15-122
Pubmed ID
Authors

Shane A Lloyd, Alayna E Loiselle, Yue Zhang, Henry J Donahue

Abstract

Connexin 43 (Cx43) is the predominant gap junction protein in bone. Mice with a bone-specific deletion of Cx43 (cKO) have an osteopenic cortical phenotype. In a recent study, we demonstrated that cKO mice are resistant to bone loss induced by hindlimb suspension (HLS), an animal model of skeletal unloading. This protective effect occurred primarily as a result of lower osteoclast-mediated bone resorption. Interestingly, we also documented a significant increase in cortical osteocyte apoptosis and reduced sclerostin production. In the present study, we investigated whether osteocytic osteolysis - bone resorption by osteocytes within lacunae - is induced by HLS and the potential effect of Cx43 deficiency on this process during unloading.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 27%
Student > Ph. D. Student 8 27%
Researcher 5 17%
Student > Master 4 13%
Professor 2 7%
Other 2 7%
Unknown 1 3%
Readers by discipline Count As %
Engineering 7 23%
Medicine and Dentistry 7 23%
Agricultural and Biological Sciences 5 17%
Biochemistry, Genetics and Molecular Biology 4 13%
Psychology 2 7%
Other 2 7%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2014.
All research outputs
#18,370,767
of 22,753,345 outputs
Outputs from BMC Musculoskeletal Disorders
#3,121
of 4,035 outputs
Outputs of similar age
#165,370
of 228,038 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#83
of 121 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,035 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.