Title |
Improving clustering with metabolic pathway data
|
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Published in |
BMC Bioinformatics, April 2014
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DOI | 10.1186/1471-2105-15-101 |
Pubmed ID | |
Authors |
Diego H Milone, Georgina Stegmayer, Mariana López, Laura Kamenetzky, Fernando Carrari |
Abstract |
It is a common practice in bioinformatics to validate each group returned by a clustering algorithm through manual analysis, according to a-priori biological knowledge. This procedure helps finding functionally related patterns to propose hypotheses for their behavior and the biological processes involved. Therefore, this knowledge is used only as a second step, after data are just clustered according to their expression patterns. Thus, it could be very useful to be able to improve the clustering of biological data by incorporating prior knowledge into the cluster formation itself, in order to enhance the biological value of the clusters. |
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