Title |
In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients
|
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Published in |
Journal of Translational Medicine, April 2014
|
DOI | 10.1186/1479-5876-12-95 |
Pubmed ID | |
Authors |
Enrico Lucarelli, Chiara Bellotti, Melissa Mantelli, Maria Antonietta Avanzini, Rita Maccario, Francesca Novara, Giulia Arrigo, Orsetta Zuffardi, Monia Zuntini, Martina Pandolfi, Luca Sangiorgi, Daniela Lisini, Davide Donati, Serena Duchi |
Abstract |
In osteosarcoma (OS) and most Ewing sarcoma (EWS) patients, the primary tumor originates in the bone. Although tumor resection surgery is commonly used to treat these diseases, it frequently leaves massive bone defects that are particularly difficult to be treated. Due to the therapeutic potential of mesenchymal stem cells (MSCs), OS and EWS patients could benefit from an autologous MSCs-based bone reconstruction. However, safety concerns regarding the in vitro expansion of bone marrow-derived MSCs have been raised. To investigate the possible oncogenic potential of MSCs from OS or EWS patients (MSC-SAR) after expansion, this study focused on a biosafety assessment of MSC-SAR obtained after short- and long-term cultivation compared with MSCs from healthy donors (MSC-CTRL). |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
India | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 38 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 27% |
Student > Master | 6 | 15% |
Student > Ph. D. Student | 5 | 12% |
Student > Postgraduate | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 5 | 12% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 22% |
Agricultural and Biological Sciences | 9 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Psychology | 2 | 5% |
Computer Science | 1 | 2% |
Other | 6 | 15% |
Unknown | 7 | 17% |