Title |
Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions
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Published in |
Journal of Neuroinflammation, December 2010
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DOI | 10.1186/1742-2094-7-95 |
Pubmed ID | |
Authors |
Timothy J Seabrook, Amanda Littlewood-Evans, Volker Brinkmann, Bernadette Pöllinger, Christian Schnell, Peter C Hiestand |
Abstract |
Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in multiple sclerosis (MS) is unclear. Central nervous system lesions from both MS and experimental autoimmune encephalomyelitis (EAE), the animal model of MS, contain T cells, macrophages and activated glia, which can produce pro-angiogenic factors. Previous EAE studies have demonstrated an increase in blood vessels, but differences between the different phases of disease have not been reported. Therefore we examined angiogenic promoting factors in MS and EAE lesions to determine if there were changes in blood vessel density at different stages of EAE. |
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