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Detection of antibiotic resistance is essential for gonorrhoea point-of-care testing: a mathematical modelling study

Overview of attention for article published in BMC Medicine, July 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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1 policy source
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17 X users

Citations

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29 Dimensions

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97 Mendeley
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Title
Detection of antibiotic resistance is essential for gonorrhoea point-of-care testing: a mathematical modelling study
Published in
BMC Medicine, July 2017
DOI 10.1186/s12916-017-0881-x
Pubmed ID
Authors

Stephanie M. Fingerhuth, Nicola Low, Sebastian Bonhoeffer, Christian L. Althaus

Abstract

Antibiotic resistance is threatening to make gonorrhoea untreatable. Point-of-care (POC) tests that detect resistance promise individually tailored treatment, but might lead to more treatment and higher levels of resistance. We investigate the impact of POC tests on antibiotic-resistant gonorrhoea. We used data about the prevalence and incidence of gonorrhoea in men who have sex with men (MSM) and heterosexual men and women (HMW) to calibrate a mathematical gonorrhoea transmission model. With this model, we simulated four clinical pathways for the diagnosis and treatment of gonorrhoea: POC test with (POC+R) and without (POC-R) resistance detection, culture and nucleic acid amplification tests (NAATs). We calculated the proportion of resistant infections and cases averted after 5 years, and compared how fast resistant infections spread in the populations. The proportion of resistant infections after 30 years is lowest for POC+R (median MSM: 0.18%, HMW: 0.12%), and increases for culture (MSM: 1.19%, HMW: 0.13%), NAAT (MSM: 100%, HMW: 99.27%), and POC-R (MSM: 100%, HMW: 99.73%). Per 100 000 persons, NAAT leads to 36 366 (median MSM) and 1228 (median HMW) observed cases after 5 years. Compared with NAAT, POC+R averts more cases after 5 years (median MSM: 3353, HMW: 118). POC tests that detect resistance with intermediate sensitivity slow down resistance spread more than NAAT. POC tests with very high sensitivity for the detection of resistance are needed to slow down resistance spread more than by using culture. POC with high sensitivity to detect antibiotic resistance can keep gonorrhoea treatable longer than culture or NAAT. POC tests without reliable resistance detection should not be introduced because they can accelerate the spread of antibiotic-resistant gonorrhoea.

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X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 96 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 19%
Student > Master 14 14%
Student > Ph. D. Student 10 10%
Student > Bachelor 9 9%
Student > Postgraduate 6 6%
Other 12 12%
Unknown 28 29%
Readers by discipline Count As %
Medicine and Dentistry 16 16%
Biochemistry, Genetics and Molecular Biology 8 8%
Agricultural and Biological Sciences 7 7%
Immunology and Microbiology 7 7%
Engineering 5 5%
Other 19 20%
Unknown 35 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2023.
All research outputs
#2,953,106
of 25,287,709 outputs
Outputs from BMC Medicine
#1,842
of 3,973 outputs
Outputs of similar age
#51,579
of 322,883 outputs
Outputs of similar age from BMC Medicine
#22
of 51 outputs
Altmetric has tracked 25,287,709 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,973 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.6. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,883 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.