Title |
Sweet taste loss in myasthenia gravis: more than a coincidence?
|
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Published in |
Orphanet Journal of Rare Diseases, April 2014
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DOI | 10.1186/1750-1172-9-50 |
Pubmed ID | |
Authors |
Joelle N Chabwine, Muriel V Tschirren, Anastasia Zekeridou, Basile N Landis, Thierry Kuntzer |
Abstract |
Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas lpr/ (MRL/lpr) transgenic mice with autoimmune disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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South Africa | 1 | 20% |
United States | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 2 | 12% |
Student > Doctoral Student | 2 | 12% |
Student > Bachelor | 2 | 12% |
Student > Master | 2 | 12% |
Professor > Associate Professor | 2 | 12% |
Other | 2 | 12% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 41% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Chemical Engineering | 1 | 6% |
Psychology | 1 | 6% |
Neuroscience | 1 | 6% |
Other | 0 | 0% |
Unknown | 6 | 35% |