Title |
Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery
|
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Published in |
Clinical Proteomics, April 2014
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DOI | 10.1186/1559-0275-11-14 |
Pubmed ID | |
Authors |
Huan Liu, Ningbo Zhang, Debin Wan, Meng Cui, Zhiqiang Liu, Shuying Liu |
Abstract |
Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for glycoprotein analysis. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
Unknown | 122 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 22% |
Student > Master | 19 | 15% |
Student > Bachelor | 16 | 13% |
Researcher | 14 | 11% |
Student > Doctoral Student | 8 | 6% |
Other | 15 | 12% |
Unknown | 26 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 32 | 25% |
Agricultural and Biological Sciences | 25 | 20% |
Biochemistry, Genetics and Molecular Biology | 16 | 13% |
Medicine and Dentistry | 10 | 8% |
Engineering | 5 | 4% |
Other | 11 | 9% |
Unknown | 27 | 21% |