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Copy number variation detection using next generation sequencing read counts

Overview of attention for article published in BMC Bioinformatics, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

twitter
17 X users
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2 patents
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
77 Dimensions

Readers on

mendeley
215 Mendeley
citeulike
3 CiteULike
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Title
Copy number variation detection using next generation sequencing read counts
Published in
BMC Bioinformatics, April 2014
DOI 10.1186/1471-2105-15-109
Pubmed ID
Authors

Heng Wang, Dan Nettleton, Kai Ying

Abstract

A copy number variation (CNV) is a difference between genotypes in the number of copies of a genomic region. Next generation sequencing (NGS) technologies provide sensitive and accurate tools for detecting genomic variations that include CNVs. However, statistical approaches for CNV identification using NGS are limited. We propose a new methodology for detecting CNVs using NGS data. This method (henceforth denoted by m-HMM) is based on a hidden Markov model with emission probabilities that are governed by mixture distributions. We use the Expectation-Maximization (EM) algorithm to estimate the parameters in the model.

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 3 1%
United Kingdom 3 1%
Norway 2 <1%
United States 2 <1%
Uruguay 1 <1%
Brazil 1 <1%
Sweden 1 <1%
South Africa 1 <1%
Germany 1 <1%
Other 4 2%
Unknown 196 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 29%
Researcher 48 22%
Student > Master 26 12%
Student > Bachelor 16 7%
Student > Postgraduate 12 6%
Other 34 16%
Unknown 16 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 106 49%
Biochemistry, Genetics and Molecular Biology 42 20%
Computer Science 19 9%
Medicine and Dentistry 15 7%
Engineering 4 2%
Other 11 5%
Unknown 18 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2021.
All research outputs
#2,107,336
of 23,975,876 outputs
Outputs from BMC Bioinformatics
#526
of 7,474 outputs
Outputs of similar age
#21,865
of 230,093 outputs
Outputs of similar age from BMC Bioinformatics
#10
of 125 outputs
Altmetric has tracked 23,975,876 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,474 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.