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The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition

Overview of attention for article published in Clinical Epigenetics, April 2014
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  • Average Attention Score compared to outputs of the same age and source

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Title
The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition
Published in
Clinical Epigenetics, April 2014
DOI 10.1186/1868-7083-6-8
Pubmed ID
Authors

Hongmei Zhang, Xin Tong, John W Holloway, Faisal I Rezwan, Gabrielle A Lockett, Veeresh Patil, Meredith Ray, Todd M Everson, Nelís Soto-Ramírez, S Hasan Arshad, Susan Ewart, Wilfried Karmaus

Abstract

Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk, that such influences are age-dependent, and that methylation of some CpG sites changes over time in accordance with asthma transition. We tested these hypotheses in subsamples of girls from a population-based birth cohort established on the Isle of Wight, UK, in 1989.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Sweden 1 2%
France 1 2%
Unknown 41 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 23%
Student > Ph. D. Student 7 16%
Student > Doctoral Student 5 11%
Student > Bachelor 4 9%
Professor 4 9%
Other 8 18%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 23%
Medicine and Dentistry 9 20%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Immunology and Microbiology 3 7%
Other 5 11%
Unknown 10 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2014.
All research outputs
#7,386,490
of 22,753,345 outputs
Outputs from Clinical Epigenetics
#542
of 1,241 outputs
Outputs of similar age
#73,770
of 226,666 outputs
Outputs of similar age from Clinical Epigenetics
#3
of 6 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,241 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,666 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.