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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages
|
|---|---|
| Published in |
Journal of Neuroinflammation, April 2014
|
| DOI | 10.1186/1742-2094-11-78 |
| Pubmed ID | |
| Authors |
Dario Siniscalco, James Jeffrey Bradstreet, Alessandra Cirillo, Nicola Antonucci |
| Abstract |
Immune system dysregulation is well-recognized in autism and thought to be part of the etiology of this disorder. The endocannabinoid system is a key regulator of the immune system via the cannabinoid receptor type 2 (CB2R) which is highly expressed on macrophages and microglial cells. We have previously published significant differences in peripheral blood mononuclear cell CB2R gene expression in the autism population. The use of the Gc protein-derived Macrophage Activating Factor (GcMAF), an endogenous glycosylated vitamin D binding protein responsible for macrophage cell activation has demonstrated positive effects in the treatment of autistic children. In this current study, we investigated the in vitro effects of GcMAF treatment on the endocannabinoid system gene expression, as well as cellular activation in blood monocyte-derived macrophages (BMDMs) from autistic patients compared to age-matched healthy developing controls. |
X Demographics
The data shown below were collected from the profiles of 33 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 27% |
| United Kingdom | 1 | 3% |
| Argentina | 1 | 3% |
| Canada | 1 | 3% |
| Spain | 1 | 3% |
| South Africa | 1 | 3% |
| Netherlands | 1 | 3% |
| Unknown | 18 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 88% |
| Practitioners (doctors, other healthcare professionals) | 3 | 9% |
| Scientists | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 16% |
| Researcher | 13 | 15% |
| Student > Bachelor | 11 | 13% |
| Student > Ph. D. Student | 9 | 11% |
| Other | 7 | 8% |
| Other | 13 | 15% |
| Unknown | 18 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 15% |
| Agricultural and Biological Sciences | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Psychology | 7 | 8% |
| Neuroscience | 4 | 5% |
| Other | 16 | 19% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 65. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2024.
All research outputs
#656,027
of 25,373,627 outputs
Outputs from Journal of Neuroinflammation
#49
of 2,951 outputs
Outputs of similar age
#5,873
of 238,626 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 39 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,626 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.