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Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity

Overview of attention for article published in BMC Pharmacology and Toxicology, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#50 of 439)
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
1 blog
twitter
1 X user
patent
1 patent

Citations

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44 Dimensions

Readers on

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55 Mendeley
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Title
Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity
Published in
BMC Pharmacology and Toxicology, April 2014
DOI 10.1186/2050-6511-15-23
Pubmed ID
Authors

Aida Attar, Wai-Ting Coco Chan, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan

Abstract

The "molecular tweezer" CLR01 is a broad-spectrum inhibitor of abnormal protein self-assembly, which acts by binding selectively to Lys residues. CLR01 has been tested in several in vitro and in vivo models of amyloidoses all without signs of toxicity. With the goal of developing CLR01 as a therapeutic drug for Alzheimer's disease and other amyloidoses, here we studied its safety and pharmacokinetics.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 25%
Student > Bachelor 10 18%
Researcher 7 13%
Other 4 7%
Professor > Associate Professor 3 5%
Other 7 13%
Unknown 10 18%
Readers by discipline Count As %
Chemistry 10 18%
Biochemistry, Genetics and Molecular Biology 8 15%
Medicine and Dentistry 6 11%
Agricultural and Biological Sciences 5 9%
Neuroscience 4 7%
Other 7 13%
Unknown 15 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 September 2021.
All research outputs
#2,859,824
of 22,753,345 outputs
Outputs from BMC Pharmacology and Toxicology
#50
of 439 outputs
Outputs of similar age
#27,185
of 203,744 outputs
Outputs of similar age from BMC Pharmacology and Toxicology
#2
of 12 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 439 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,744 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.