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LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5

Overview of attention for article published in Neural Development, April 2014
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Title
LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5
Published in
Neural Development, April 2014
DOI 10.1186/1749-8104-9-7
Pubmed ID
Authors

Matthew L O’Sullivan, Francesca Martini, Sventja von Daake, Davide Comoletti, Anirvan Ghosh

Abstract

Latrophilins (LPHNs) are a small family of neuronal adhesion-GPCRs originally discovered as receptors for the black widow spider toxin α-latrotoxin. Mutations in LPHN3 have recently been identified as risk factors for attention deficit hyperactivity disorder (ADHD) in humans, but their physiological function has remained elusive. In this study, we tested two hypotheses regarding LPHN3 function: (1) LPHN3 regulates synaptic transmission by modulating probability of release; and (2) LPHN3 controls synapse development and the abundance of synapses.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Netherlands 1 <1%
Germany 1 <1%
Unknown 109 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 18%
Researcher 18 16%
Student > Bachelor 15 13%
Student > Master 14 13%
Student > Postgraduate 5 4%
Other 16 14%
Unknown 24 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 24%
Neuroscience 21 19%
Biochemistry, Genetics and Molecular Biology 18 16%
Medicine and Dentistry 8 7%
Psychology 5 4%
Other 7 6%
Unknown 26 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2014.
All research outputs
#20,228,193
of 22,753,345 outputs
Outputs from Neural Development
#206
of 226 outputs
Outputs of similar age
#192,486
of 226,127 outputs
Outputs of similar age from Neural Development
#6
of 7 outputs
Altmetric has tracked 22,753,345 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 226 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,127 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
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