Title |
Prevention of catheter lumen occlusion with rT-PA versus heparin (Pre-CLOT): study protocol of a randomized trial [ISRCTN35253449]
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Published in |
BMC Nephrology, April 2006
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DOI | 10.1186/1471-2369-7-8 |
Pubmed ID | |
Authors |
Brenda R Hemmelgarn, Louise Moist, Rachel M Pilkey, Charmaine Lok, Marc Dorval, Paul YW Tam, Murray J Berall, Martine LeBlanc, Edwin B Toffelmire, Braden J Manns, Nairne Scott-Douglas |
Abstract |
Many patients with end-stage renal disease use a central venous catheter for hemodialysis access. A large majority of these catheters malfunction within one year of insertion, with up to two-thirds due to thrombosis. The optimal solution for locking the catheter between hemodialysis sessions, to decrease the risk of thrombosis and catheter malfunction, is unknown. The Prevention of Catheter Lumen Occlusion with rt-PA versus Heparin (PreCLOT) study will determine if use of weekly rt-PA, compared to regular heparin, as a catheter locking solution, will decrease the risk of catheter malfunction. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 19% |
Student > Master | 6 | 14% |
Student > Bachelor | 6 | 14% |
Student > Postgraduate | 4 | 9% |
Researcher | 4 | 9% |
Other | 9 | 21% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 60% |
Nursing and Health Professions | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Computer Science | 1 | 2% |
Biochemistry, Genetics and Molecular Biology | 1 | 2% |
Other | 2 | 5% |
Unknown | 6 | 14% |