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Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells

Overview of attention for article published in Cancer Cell International, January 2014
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1 tweeter

Citations

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24 Mendeley
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Title
Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells
Published in
Cancer Cell International, January 2014
DOI 10.1186/1475-2867-14-35
Pubmed ID
Authors

Aaron L Miller, Chuandong Geng, Georgiy Golovko, Meenakshi Sharma, Jason R Schwartz, Jiabin Yan, Lawrence Sowers, William R Widger, Yuriy Fofanov, Wayne V Vedeckis, E Thompson

Abstract

Glucocorticoids (GCs) are often included in the therapy of lymphoid malignancies because they kill several types of malignant lymphoid cells. GCs activate the glucocorticoid receptor (GR), to regulate a complex genetic network, culminating in apoptosis. Normal lymphoblasts and many lymphoid malignancies are sensitive to GC-driven apoptosis. Resistance to GCs can be a significant clinical problem, however, and correlates with resistance to several other major chemotherapeutic agents.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 29%
Researcher 4 17%
Student > Bachelor 3 13%
Other 2 8%
Student > Doctoral Student 2 8%
Other 4 17%
Unknown 2 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 33%
Biochemistry, Genetics and Molecular Biology 4 17%
Medicine and Dentistry 4 17%
Chemistry 2 8%
Engineering 2 8%
Other 1 4%
Unknown 3 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2014.
All research outputs
#10,052,791
of 12,566,211 outputs
Outputs from Cancer Cell International
#245
of 471 outputs
Outputs of similar age
#127,517
of 189,161 outputs
Outputs of similar age from Cancer Cell International
#4
of 4 outputs
Altmetric has tracked 12,566,211 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 471 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,161 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.