Title |
Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
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Published in |
BMC Neuroscience, April 2014
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DOI | 10.1186/1471-2202-15-51 |
Pubmed ID | |
Authors |
Pooja Naik, Neel Fofaria, Shikha Prasad, Ravi K Sajja, Babette Weksler, Pierre-Olivier Couraud, Ignacio A Romero, Luca Cucullo |
Abstract |
Both active and passive tobacco smoke (TS) potentially impair the vascular endothelial function in a causative and dose-dependent manner, largely related to the content of reactive oxygen species (ROS), nicotine, and pro-inflammatory activity. Together these factors can compromise the restrictive properties of the blood-brain barrier (BBB) and trigger the pathogenesis/progression of several neurological disorders including silent cerebral infarction, stroke, multiple sclerosis and Alzheimer's disease. Based on these premises, we analyzed and assessed the toxic impact of smoke extract from a range of tobacco products (with varying levels of nicotine) on brain microvascular endothelial cell line (hCMEC/D3), a well characterized human BBB model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 86 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 22% |
Student > Bachelor | 12 | 14% |
Researcher | 12 | 14% |
Student > Doctoral Student | 8 | 9% |
Student > Master | 7 | 8% |
Other | 16 | 18% |
Unknown | 14 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 26% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Agricultural and Biological Sciences | 11 | 13% |
Neuroscience | 7 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 10 | 11% |
Unknown | 21 | 24% |