Title |
Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia
|
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Published in |
BMC Medicine, April 2014
|
DOI | 10.1186/1741-7015-12-67 |
Pubmed ID | |
Authors |
Peter Olupot-Olupot, Charles Engoru, Jennifer Thompson, Julius Nteziyaremye, Martin Chebet, Tonny Ssenyondo, Cornelius M Dambisya, Vicent Okuuny, Ronald Wokulira, Denis Amorut, Paul Ongodia, Ayub Mpoya, Thomas N Williams, Sophie Uyoga, Alex Macharia, Diana M Gibb, A Sarah Walker, Kathryn Maitland |
Abstract |
Severe anemia (SA, hemoglobin <6 g/dl) is a leading cause of pediatric hospital admission in Africa, with significant in-hospital mortality. The underlying etiology is often infectious, but specific pathogens are rarely identified. Guidelines developed to encourage rational blood use recommend a standard volume of whole blood (20 ml/kg) for transfusion, but this is commonly associated with a frequent need for repeat transfusion and poor outcome. Evidence is lacking on what hemoglobin threshold criteria for intervention and volume are associated with the optimal survival outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Italy | 2 | 2% |
Ethiopia | 1 | 1% |
United Kingdom | 1 | 1% |
Unknown | 95 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 14 | 14% |
Student > Bachelor | 12 | 12% |
Other | 10 | 10% |
Researcher | 7 | 7% |
Student > Postgraduate | 6 | 6% |
Other | 19 | 19% |
Unknown | 31 | 31% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 45 | 45% |
Nursing and Health Professions | 5 | 5% |
Social Sciences | 4 | 4% |
Agricultural and Biological Sciences | 3 | 3% |
Engineering | 2 | 2% |
Other | 8 | 8% |
Unknown | 32 | 32% |