Title |
Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors
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Published in |
Radiation Oncology, December 2007
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DOI | 10.1186/1748-717x-2-39 |
Pubmed ID | |
Authors |
Brian T Collins, Kelly Erickson, Cristina A Reichner, Sean P Collins, Gregory J Gagnon, Sonja Dieterich, Don A McRae, Ying Zhang, Shadi Yousefi, Elliot Levy, Thomas Chang, Carlos Jamis-Dow, Filip Banovac, Eric D Anderson |
Abstract |
Recent developments in radiotherapeutic technology have resulted in a new approach to treating patients with localized lung cancer. We report preliminary clinical outcomes using stereotactic radiosurgery with real-time tumor motion tracking to treat small peripheral lung tumors. Eligible patients were treated over a 24-month period and followed for a minimum of 6 months. Fiducials (3-5) were placed in or near tumors under CT-guidance. Non-isocentric treatment plans with 5-mm margins were generated. Patients received 45-60 Gy in 3 equal fractions delivered in less than 2 weeks. CT imaging and routine pulmonary function tests were completed at 3, 6, 12, 18, 24 and 30 months. Twenty-four consecutive patients were treated, 15 with stage I lung cancer and 9 with single lung metastases. Pneumothorax was a complication of fiducial placement in 7 patients, requiring tube thoracostomy in 4. All patients completed radiation treatment with minimal discomfort, few acute side effects and no procedure-related mortalities. Following treatment transient chest wall discomfort, typically lasting several weeks, developed in 7 of 11 patients with lesions within 5 mm of the pleura. Grade III pneumonitis was seen in 2 patients, one with prior conventional thoracic irradiation and the other treated with concurrent Gefitinib. A small statistically significant decline in the mean % predicted DLCO was observed at 6 and 12 months. All tumors responded to treatment at 3 months and local failure was seen in only 2 single metastases. There have been no regional lymph node recurrences. At a median follow-up of 12 months, the crude survival rate is 83%, with 3 deaths due to co-morbidities and 1 secondary to metastatic disease. Radical stereotactic radiosurgery with real-time tumor motion tracking is a promising well-tolerated treatment option for small peripheral lung tumors. |
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Unknown | 62 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 14 | 21% |
Researcher | 11 | 16% |
Student > Master | 8 | 12% |
Student > Bachelor | 7 | 10% |
Student > Ph. D. Student | 7 | 10% |
Other | 14 | 21% |
Unknown | 7 | 10% |
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Physics and Astronomy | 8 | 12% |
Engineering | 4 | 6% |
Nursing and Health Professions | 2 | 3% |
Psychology | 1 | 1% |
Other | 3 | 4% |
Unknown | 16 | 24% |