↓ Skip to main content

H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments

Overview of attention for article published in BMC Bioinformatics, April 2014
Altmetric Badge

Mentioned by

twitter
2 X users

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
34 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments
Published in
BMC Bioinformatics, April 2014
DOI 10.1186/1471-2105-15-118
Pubmed ID
Authors

Jan-Oliver Janda, Ajmal Popal, Jochen Bauer, Markus Busch, Michael Klocke, Wolfgang Spitzer, Jörg Keller, Rainer Merkl

Abstract

The identification of functionally important residue positions is an important task of computational biology. Methods of correlation analysis allow for the identification of pairs of residue positions, whose occupancy is mutually dependent due to constraints imposed by protein structure or function. A common measure assessing these dependencies is the mutual information, which is based on Shannon's information theory that utilizes probabilities only. Consequently, such approaches do not consider the similarity of residue pairs, which may degrade the algorithm's performance. One typical algorithm is H2r, which characterizes each individual residue position k by the conn(k)-value, which is the number of significantly correlated pairs it belongs to.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 6%
United Kingdom 1 3%
Japan 1 3%
Germany 1 3%
Unknown 29 85%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 35%
Researcher 8 24%
Student > Master 5 15%
Professor 2 6%
Student > Postgraduate 2 6%
Other 2 6%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 38%
Computer Science 6 18%
Chemistry 4 12%
Biochemistry, Genetics and Molecular Biology 3 9%
Chemical Engineering 1 3%
Other 1 3%
Unknown 6 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2014.
All research outputs
#18,371,293
of 22,754,104 outputs
Outputs from BMC Bioinformatics
#6,302
of 7,269 outputs
Outputs of similar age
#163,705
of 226,688 outputs
Outputs of similar age from BMC Bioinformatics
#106
of 133 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,269 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,688 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.