Title |
Short course daily prednisolone therapy during an upper respiratory tract infection in children with relapsing steroid-sensitive nephrotic syndrome (PREDNOS 2): protocol for a randomised controlled trial
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Published in |
Trials, April 2014
|
DOI | 10.1186/1745-6215-15-147 |
Pubmed ID | |
Authors |
Nicholas J A Webb, Emma Frew, Elizabeth A Brettell, David V Milford, Detlef Bockenhauer, Moin A Saleem, Martin Christian, Angela S Hall, Ania Koziell, Heather Maxwell, Shivram Hegde, Eric R Finlay, Rodney D Gilbert, Jenny Booth, Caroline Jones, Karl McKeever, Wendy Cook, Natalie J Ives |
Abstract |
Relapses of childhood steroid-sensitive nephrotic syndrome (SSNS) are treated with a 4- to 8-week course of high-dose oral prednisolone, which may be associated with significant adverse effects. There is a clear association between upper respiratory tract infection (URTI) and relapse development. Previous studies in developing nations have suggested that introducing a 5- to 7-day course of daily prednisolone during an URTI may prevent a relapse developing and the need for a treatment course of high-dose prednisolone. The aim of PREDNOS 2 is to evaluate the effectiveness of a 6-day course of daily prednisolone therapy during an URTI in reducing the development of a subsequent relapse in a developed nation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | 60% |
United States | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 106 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 11% |
Student > Master | 12 | 11% |
Researcher | 11 | 10% |
Student > Bachelor | 11 | 10% |
Student > Doctoral Student | 7 | 7% |
Other | 20 | 19% |
Unknown | 33 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 40 | 38% |
Nursing and Health Professions | 7 | 7% |
Psychology | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Economics, Econometrics and Finance | 3 | 3% |
Other | 9 | 8% |
Unknown | 37 | 35% |