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Short course daily prednisolone therapy during an upper respiratory tract infection in children with relapsing steroid-sensitive nephrotic syndrome (PREDNOS 2): protocol for a randomised controlled…

Overview of attention for article published in Trials, April 2014
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Title
Short course daily prednisolone therapy during an upper respiratory tract infection in children with relapsing steroid-sensitive nephrotic syndrome (PREDNOS 2): protocol for a randomised controlled trial
Published in
Trials, April 2014
DOI 10.1186/1745-6215-15-147
Pubmed ID
Authors

Nicholas J A Webb, Emma Frew, Elizabeth A Brettell, David V Milford, Detlef Bockenhauer, Moin A Saleem, Martin Christian, Angela S Hall, Ania Koziell, Heather Maxwell, Shivram Hegde, Eric R Finlay, Rodney D Gilbert, Jenny Booth, Caroline Jones, Karl McKeever, Wendy Cook, Natalie J Ives

Abstract

Relapses of childhood steroid-sensitive nephrotic syndrome (SSNS) are treated with a 4- to 8-week course of high-dose oral prednisolone, which may be associated with significant adverse effects. There is a clear association between upper respiratory tract infection (URTI) and relapse development. Previous studies in developing nations have suggested that introducing a 5- to 7-day course of daily prednisolone during an URTI may prevent a relapse developing and the need for a treatment course of high-dose prednisolone. The aim of PREDNOS 2 is to evaluate the effectiveness of a 6-day course of daily prednisolone therapy during an URTI in reducing the development of a subsequent relapse in a developed nation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 106 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 11%
Student > Master 12 11%
Researcher 11 10%
Student > Bachelor 11 10%
Student > Doctoral Student 7 7%
Other 20 19%
Unknown 33 31%
Readers by discipline Count As %
Medicine and Dentistry 40 38%
Nursing and Health Professions 7 7%
Psychology 6 6%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Economics, Econometrics and Finance 3 3%
Other 9 8%
Unknown 37 35%