Title |
Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71
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Published in |
Journal of Biomedical Science, April 2014
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DOI | 10.1186/1423-0127-21-33 |
Pubmed ID | |
Authors |
Sheng-Wen Huang, Hui-Li Cheng, Hsin-Yi Hsieh, Chia-Lun Chang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Ih-Jen Su, Jen-Ren Wang |
Abstract |
Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbreaks during 1998-2008 in Taiwan, genotype B5 was responsible for two large outbreaks in 2008 and 2012, respectively. In China, by contrast, EV71 often persists as a single genotype in the population and causes frequent outbreaks. To investigate genetic changes in viral evolution, complete EV71 genome sequences were used to analyze the intra-genotypic evolution pattern in Taiwan, China, and the Netherlands. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 7 | 24% |
Student > Ph. D. Student | 7 | 24% |
Researcher | 5 | 17% |
Professor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 4 | 14% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 13 | 45% |
Medicine and Dentistry | 5 | 17% |
Immunology and Microbiology | 3 | 10% |
Nursing and Health Professions | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Other | 2 | 7% |
Unknown | 2 | 7% |