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Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters

Overview of attention for article published in Breast Cancer Research, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

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7 X users
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2 Facebook pages

Citations

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87 Dimensions

Readers on

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174 Mendeley
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Title
Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters
Published in
Breast Cancer Research, April 2014
DOI 10.1186/bcr3649
Pubmed ID
Authors

Leena Hilakivi-Clarke

Abstract

The idea that susceptibility to breast cancer is determined not only through inherited germline mutations but also by epigenetic changes induced by alterations in hormonal environment during fetal development is gaining increasing support. Using findings obtained in human and animal studies, this review addresses the mechanisms that may explain why daughters of mothers who took synthetic estrogen diethylstilbestrol (DES) during pregnancy have two times higher breast cancer risk than women who were not exposed to it. The mechanisms likely involve epigenetic alterations, such as increased DNA methylation and modifications in histones and microRNA expression.Further, these alterations may target genes that regulate stem cells and prevent differentiation of their daughter cells. Recent findings in a preclinical model suggest that not only are women exposed to DES in utero at an increased risk of developing breast cancer, but this risk may extend to their daughters and granddaughters as well. It is critical, therefore, to determine if the increased risk is driven by epigenetic alterations in genes that increase susceptibility to breast cancer and if these alterations are reversible.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 174 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 <1%
Unknown 173 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 12%
Student > Master 21 12%
Student > Bachelor 17 10%
Researcher 14 8%
Student > Doctoral Student 9 5%
Other 28 16%
Unknown 64 37%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 32 18%
Medicine and Dentistry 25 14%
Agricultural and Biological Sciences 19 11%
Pharmacology, Toxicology and Pharmaceutical Science 8 5%
Nursing and Health Professions 5 3%
Other 16 9%
Unknown 69 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2023.
All research outputs
#6,196,308
of 25,216,325 outputs
Outputs from Breast Cancer Research
#712
of 2,043 outputs
Outputs of similar age
#53,992
of 233,987 outputs
Outputs of similar age from Breast Cancer Research
#12
of 38 outputs
Altmetric has tracked 25,216,325 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,043 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.