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Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

Overview of attention for article published in Breast Cancer Research, April 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

twitter
1 tweeter
patent
4 patents

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
26 Mendeley
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Title
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening
Published in
Breast Cancer Research, April 2014
DOI 10.1186/bcr3645
Pubmed ID
Authors

Sireesha V Garimella, Kristie Gehlhaus, Jennifer L Dine, Jason J Pitt, Magdalena Grandin, Sirisha Chakka, Marion M Nau, Natasha J Caplen, Stanley Lipkowitz

Abstract

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with a mesenchymal phenotype are sensitive to TRAIL while other breast cancer cell lines are resistant. The underlying mechanisms that control TRAIL sensitivity in breast cancer cells are not well understood. Here, we performed small interfering RNA (siRNA) screens to identify molecular regulators of the TRAIL pathway in breast cancer cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 38%
Student > Master 7 27%
Researcher 3 12%
Student > Bachelor 2 8%
Other 1 4%
Other 2 8%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 50%
Computer Science 3 12%
Immunology and Microbiology 2 8%
Biochemistry, Genetics and Molecular Biology 2 8%
Medicine and Dentistry 2 8%
Other 2 8%
Unknown 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2021.
All research outputs
#6,459,524
of 21,353,399 outputs
Outputs from Breast Cancer Research
#776
of 1,836 outputs
Outputs of similar age
#60,494
of 204,534 outputs
Outputs of similar age from Breast Cancer Research
#14
of 44 outputs
Altmetric has tracked 21,353,399 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,836 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,534 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.