Title |
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential
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Published in |
BMC Genomics, March 2007
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DOI | 10.1186/1471-2164-8-73 |
Pubmed ID | |
Authors |
Princy Francis, Heidi Maria Namløs, Christoph Müller, Patrik Edén, Josefin Fernebro, Jeanne-Marie Berner, Bodil Bjerkehagen, Måns Åkerman, Pär-Ola Bendahl, Anna Isinger, Anders Rydholm, Ola Myklebost, Mef Nilbert |
Abstract |
Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of STS metastasize and current risk-stratification is suboptimal, therefore, novel diagnostic and prognostic markers would be clinically valuable. We assessed the diagnostic and prognostic value of array-based gene expression profiles using 27 k cDNA microarrays in 177, mainly high-grade, STS of 13 histopathological subtypes. |
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United Kingdom | 1 | 1% |
Canada | 1 | 1% |
China | 1 | 1% |
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Unknown | 76 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 26% |
Student > Ph. D. Student | 17 | 21% |
Professor | 8 | 10% |
Other | 6 | 7% |
Student > Bachelor | 5 | 6% |
Other | 15 | 18% |
Unknown | 10 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 29% |
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Biochemistry, Genetics and Molecular Biology | 14 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Computer Science | 1 | 1% |
Other | 6 | 7% |
Unknown | 14 | 17% |