Title |
Sensory cortex lesion triggers compensatory neuronal plasticity
|
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Published in |
BMC Neuroscience, May 2014
|
DOI | 10.1186/1471-2202-15-57 |
Pubmed ID | |
Authors |
Manfred Depner, Konstantin Tziridis, Andreas Hess, Holger Schulze |
Abstract |
Lesions to the human brain often cause dramatic impairments in the life of patients because of the very limited capacity of the mammalian nervous system to regenerate. On the other hand, neuronal tissue has a high capacity to reorganize itself so that loss of function due to brain damage may be compensated through neuroplastic reorganization of undamaged tissue in brain regions adjacent or contralateral to the lesion site. In this study we investigated the effect of serial lesions of the auditory cortices (AC) in both hemispheres of Mongolian gerbils on discrimination performance for fast amplitude modulated tones (AM). Healthy animals were trained to discriminate two fast AM, an ability that has previously been shown to critically depend on cortical processing. Their ability to maintain significant discrimination performance was retested after unilateral AC lesion, and again after lesion of the contralateral AC, with 15 days of continuing training in between the two lesions. |
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Country | Count | As % |
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United Kingdom | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 20% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
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Student > Ph. D. Student | 6 | 15% |
Researcher | 5 | 13% |
Student > Doctoral Student | 4 | 10% |
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Other | 5 | 13% |
Unknown | 8 | 21% |