Title |
Acute graft versus host disease after orthotopic liver transplantation
|
---|---|
Published in |
Journal of Hematology & Oncology, August 2012
|
DOI | 10.1186/1756-8722-5-50 |
Pubmed ID | |
Authors |
Inga Mandac Rogulj, Joachim Deeg, Stephanie J Lee |
Abstract |
Graft versus host disease (GVHD) is an uncommon complication after orthotopic liver transplantation (OLT) with an incidence of 0.1-2%, but an 80-100% mortality rate. Patients can present with skin rashes, diarrhea, and bone marrow aplasia between two to eight weeks after OLT. Diagnosis of GVHD is made based on clinical and histologic evidence, supported by chimerism studies showing donor HLA alleles in the recipient bone marrow or blood. Several therapeutic approaches have been used for the management of GVHD after OLT including increased immunosuppression, decreased immunosuppression, and cellular therapies. However, success rates have been low, and new approaches are needed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 50 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 14 | 27% |
Professor > Associate Professor | 9 | 18% |
Researcher | 5 | 10% |
Student > Bachelor | 5 | 10% |
Student > Postgraduate | 4 | 8% |
Other | 10 | 20% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 33 | 65% |
Agricultural and Biological Sciences | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 4% |
Unknown | 7 | 14% |