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Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells

Overview of attention for article published in BMC Research Notes, April 2014
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Title
Butyrate induced changes in Wnt-signaling specific gene expression in colorectal cancer cells
Published in
BMC Research Notes, April 2014
DOI 10.1186/1756-0500-7-226
Pubmed ID
Authors

Darina L Lazarova, Christopher Chiaro, Michael Bordonaro

Abstract

We have determined that butyrate, which is derived from the fermentation of dietary fiber in the colonic lumen, hyperactivates Wnt activity in colorectal (CRC) cells, and that this upregulation of Wnt signaling is causatively related to the induction of apoptosis. To better understand the genetic program regulated by butyrate-mediated Wnt hyperactivation, we performed total human genome microarray analyses on HCT-116 CRC cells in the presence or absence of a physiologically relevant concentration of butyrate. To evaluate changes in Wnt-specific gene expression, Wnt activity was suppressed with inducible dominant negative Tcf4 (DN-Tcf4). Six biological replicates of a full human genome microarray were performed, and the data deposited into the Gene Expression Omnibus database, according to Minimum Information About A Microarray Experiment standards.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 21%
Student > Bachelor 5 12%
Student > Doctoral Student 3 7%
Researcher 3 7%
Student > Master 3 7%
Other 7 16%
Unknown 13 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 23%
Biochemistry, Genetics and Molecular Biology 7 16%
Medicine and Dentistry 4 9%
Immunology and Microbiology 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 9%
Unknown 15 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#15,249,325
of 22,755,127 outputs
Outputs from BMC Research Notes
#2,299
of 4,262 outputs
Outputs of similar age
#134,063
of 228,039 outputs
Outputs of similar age from BMC Research Notes
#44
of 78 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,262 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,039 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.